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In the exploration of the general mechanism underlying erastin/RSL3-induced ferroptosis, it has been noted that both compounds inactivate GPX4, as RSL3 directly inactivates GPX4, while erastin indirectly inactivates GPX4 by preventing the import of cystine, leading to the deprivation of cysteine, a crucial building block of GSH and cellular antioxidants
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Testicular cancer and occupational exposure to polyvinyl chloride plastics: a case-control study
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