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reported that LKB1 mutation in KRAS mutant lung adenocarcinoma confers a glutamate enriched phenotype in TME, and this feature was associated with CD8 + T cell activation against PD-1, whereas treatment with the glutaminase inhibitor CB-839 inhibited CD8 + T cell expansion and activation
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Synaptosomal bioenergetic defects are associated with cognitive impairment in a transgenic rat model of early Alzheimer’s disease
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