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Similarly, diet supplementation with FGS significantly reduced intestinal βGLU activity, leading to a marked reduction in tumour incidence from 93.3% in male Wister rats receiving DMH alone for 15 weeks to 16.6% in rats receiving DMH + 2 g/kg FGS water extracts for 30-weeks cumulative period

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Under hypoxic conditions, elevated lactate levels stimulate H3K18la at the HIF-1α promoter, leading to upregulation of HIF-1α expression (115)