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Folate, vitamin B6, and vitamin B12 are all required for the conversion of homocysteine into the sulfur-containing amino acid methionine

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Future breeding programs must move beyond targeting individual traits to a systems-based strategy: aiming pyramiding alleles for short-term acclimation (e.g., antioxidant efficiency) with those for long-term structural adaptation (e.g., deep rooting), using genomic prediction models to identify optimal allelic combinations for target environments