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Given that the GCLC subunit is required for all GCL-catalyzed γ-GC synthesis, cells lacking Gclc do not have the capacity for de novo synthesis of GSH
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Many of these cardiovascular pathologies, during their development, generate a state of oxidative stress that leads to a deterioration in the patient’s conditions associated with the generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS)
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