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Simultaneously, perturbation of the electron transport chain and TCA-cycle enzymes (e.g., citrate synthase, α-ketoglutarate dehydrogenase) increases electron leakage and ROS formation, driving lipid peroxidation and oxidative damage to proteins and nucleic acids

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Approximately 900 adult participants were enrolled across six randomized, double-blind, placebo-controlled clinical trials conducted between 2001 and 2006