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Semaglutide Mechanism of Action Semaglutide achieves weight loss through multiple complementary pathways: Central appetite suppression — acts on hypothalamic GLP-1 receptors to reduce hunger and increase satiety Delayed gastric emptying — slows stomach emptying, prolonging feelings of fullness Improved insulin sensitivity — reduces insulin resistance and promotes healthy glucose metabolism Reward pathway modulation — reduces cravings and food-seeking behavior by acting on mesolimbic dopamine circuits Potential direct effects on adipose tissue — emerging research suggests GLP-1 may directly influence fat metabolism For a complete breakdown of semaglutide's dosing protocol, see our semaglutide dosing schedule week-by-week guide