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The protective effect of curcumin against lipid and protein oxidation and activation of antioxidant enzymes, together with its effects on reducing the production of malondialdehyde, protein carbonyls, thiols, and nitrotyrosines — which target multiple molecular targets and signaling pathways — accounts for its neuroprotective effects [162] in several conditions including AD and PD

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Early human studies further suggest improvements in subjective sleep quality, daytime alertness, and overall sleep satisfaction, highlighting its potential as a targeted approach to supporting restorative sleep rather than simply increasing sleep duration