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Methods Ethics approval All of Us (All of Us Institutional Review Board), UK Biobank (North West Multi-centre Research Ethics Committee/North West–Haydock Research Ethics Committee), FinnGen (Coordinating Ethics Committee of the Hospital District of Helsinki and Uusimaa), Estonian Biobank (Estonian Committee on Bioethics and Human Research, Estonian Ministry of Social Affairs), Genes & Health (London–South East Research Ethics Committee/NRES Committee London–South East), Mass General Brigham Biobank (Mass General Brigham Institutional Review Board/Mass General Brigham Human Research Committee), Michigan Genomics Initiative (University of Michigan Medical School Institutional Review Board), deCODE Genetics/Amgen Iceland (National Bioethics Committee of Iceland and Icelandic Data Protection Authority), Copenhagen Hospital Biobank (CHB