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While relatively few kidney-targeting peptides are available, the synthetic peptide (KKEEE) 3 K [143], which was previously found to target the kidneys through the megalin receptor, has been explored in multiple, recent studies [143–145]
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Studies have shown significantly elevated ROS and lipid peroxidation levels in the semen of affected patients (35, 37), which correlate positively with sperm DNA fragmentation rates (38)
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