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This procedure depends on several carriers and enzymes, such as mitochondrial citrate carrier, acetyl-CoA carboxylase, fatty acid synthase, diacylglycerol, acyltransferase, and stearoyl-CoA desaturase 1.[48] Several nuclear transcription factors have also been implicated in this biochemical procedure, such as sterol regulatory element-binding proteins, carbohydrate-responsive element binding protein, liver X receptor α, farnesoid X receptor, and peroxisome proliferator-activated receptors.[48] As mentioned before, liver fatty acid oxidation occurs primarily within the mitochondria, being transported into the mitochondrial matrix by a carnitine-dependent enzyme shuttle

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