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Numerous studies have demonstrated that sorafenib showed potent induction of ferroptosis in various cancers, unravelling novel mechanisms through which sorafenib induced this process [35, 59, 60]
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In addition to providing protection against oxidative damage, the Trx and GSH systems also play important roles in cell proliferation, redox regulation of gene expression, xenobiotic metabolism, and several other metabolic functions [8,9]
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