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These findings are a caution against oversimplified narratives: TREK-1's role in the brain is region-specific and context-dependent, and chronic blockade could plausibly carry risks in certain neurovascular settings that rodent depression models would not detect
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We find that although HGF/c-MET-targeted therapy has led to breakthroughs in certain cancers, monotherapy of targeting HGF/c-MET has failed to demonstrate significant clinical efficacy in most cancers
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