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One trial (NCT03733119) was designed to examine whether methionine restriction metabolically primes metastatic triple-negative breast cancer to respond to a novel TRAIL agonist (ONC201) based on preclinical findings from our lab and others that methionine deprivation induces expression of TRAIL-R2 and sensitizes tumors to TRAIL-R2 agonists [150,151]
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187 mTORC1 also regulates autophagy at the transcriptional level by modulating the localization of TFEB, which regulates the expression of autophagy and lysosomal genes
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