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These models have provided crucial insights into the immunological pathways that drive autoimmune thyroid diseases and have been essential for developing potential immunomodulatory therapies aimed at modulating the autoimmune response in Hashimoto’s thyroiditis (Qian et al
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135 Therefore, the canonical Wnt signalling pathway is considered the main mechanism of RSPO2 regulation, and it has been proposed that it may be a more precise bone mass regulator
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