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This is because MK-4 is primarily synthesized endogenously from vitamin K1 by the UbiA prenyltransferase domaining containing 1 ( UBIAD1 ) enzyme in extrahepatic tissues [31,32]
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In order to investigate the mechanisms underlying APR-246 activity against AML cells, we exposed the cells treated with APR-246 to inhibitors of various cell death pathways (Figure 2A)
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