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Phytoconstituents as therapeutic agents in combating methotrexate-induced hepatotoxicity and nephrotoxicity: Expert Opinion on Drug Metabolism & Toxicology: Vol 21, No 11-12
This was achieved by inhibiting the expression of proteins such as VEGF, CD34, COX-2, and MMP-9/TIMP-1 (Huixing et al., 2014)
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Individual circulating factors, including nutrients, metabolites, and hormones, are also capable of inducing cellular senescence
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