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Interestingly, PMA-induced ERK activity was substantially stronger in Gsr −/− neutrophils than in similarly treated WT neutrophils, although PMA-stimulated p38 activity was similar in the two groups (Fig

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To counteract this, functional outer membrane TSPO binds cholesterol to stabilize its confirmation and enzymatically catalyzes the oxidative cleavage of PpIX into bilindigin, neutralizing its phototoxic capacity