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Furthermore, treatment of rat hippocampal cells and SHSY5Y human neuroblastoma cells with H 2 O 2 at the early stages of oxidative stress exposure results in tau dephosphorylation at the tau1 epitope by CDK5 via Pin1 activation (203)

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In summary, despite many studies indicating the oral administration of vitamin B12 to be easy, effective and less costly than intramuscular administration, their designs, and in some cases their methodological limitations, mean that debate still surrounds the effectiveness of the oral route