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1.4.3 Limitations of benign and VUS classifications Ultimately, WES is not a genetic oracle, and in contrast to Mendelian diseases– which often result from single-gene coding variants (Botstein and Risch, 2003), several complex traits could be driven by noncoding variants that presumably affect gene regulation
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The key distinction is that normal vaccine soreness is mild, self-limited, and improves steadily , whereas SIRVA involves severe pain, functional limitation, and persistence beyond one week
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