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NITRIC OXIDE SYNTHESIS, SIGNALING MECHANISMS, & INACTIVATION Synthesis NO, written as NO • to indicate an unpaired electron in its chemical structure, or simply NO, is a highly reactive signaling molecule that is made by any of three closely related NO synthase (NOS, EC 1.14.13.49) isoenzymes, each of which is encoded by a separate gene and named for the initial cell type from which it was isolated ( Table 19–1 )
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