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The damaged sites also showed an upregulation of antioxidant enzymes, including HO-1, compared to normal-appearing white matter and white matter tissue from control brains with no neurological disease, and HO-1 immunoreactivity was particularly confined to microglia [61]
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Chronic alcohol abuse through oxidative reduction response and inflammatory activation leads to cytoskeletal destabilization of BBB integrity, which further activates astrocytes and thus finally causes BBB disruption and neuronal death [68]
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