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Development of inhaled DPP1 inhibitors aims to optimize treatment safety and efficacy by directly acting on lung target organs ( Precision medicine for DPP1 inhibitor therapy hinges on identifying the right patients—particularly those with high sputum neutrophil counts and NSP activity, who tend to respond better to treatment (Sibila et al., 2019)
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In this setting, Cys2 is known to increase the activity of betaine-homocysteine methyltransferase-this is the so-called Cys2-sparing effect of Met, which is readily observed when Cys2 is added to a low-Met diet in animal models (20)
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