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🩸 Anemia of Chronic Disease (ACD): - Low serum iron - Low/normal TIBC - Normal or high ferritin - Low transferrin saturation - Normocytic, normochromic RBCs - Reticulocyte count: Low → blunted response to iron therapy
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Importantly, metformin exerts an acute glucose-lowering effect in liver-specific [201] and intestine-specific [202] AMPK knockout mouse models, indicating the presence of AMPK-independent mechanisms (reviewed in Ref
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