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Figure 1 Cysteine catabolism cannot be addressed without mentioning that de novo cysteine synthesis occurs through the transsulfuration pathway (TSP), deriving from methionine and serine (Figure 1B), which makes the synthesis of cysteine dependent on the availability of methionine cycle intermediates ( Pyruvate kinase (PK) is considered a main regulator of energy homeostasis by the generation of glucose-derived pyruvate ( One-Carbon Metabolism Concurrently Depends on and Controls Cysteine Bioavailability The one-carbon metabolism is constituted by the methionine cycle and the folate cycle, which are dependent on serine and glycine bioavailability and from which certain intermediates are deviated to form cysteine (Figure 1B)