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In contrast, ferroptotic neurons secrete damage-associated molecular patterns (DAMPs), oxidized phospholipids and excess iron, all of which can lead to activation of pattern-recognition receptors, nuclear factor kappa B (NF-κB), and inflammasome signaling in the glial cells, thus sustaining chronic neuroinflammation and progressive neuronal degeneration (Li J
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Recent data implicate a secreted form of thioredoxin in control of cell growth, where the redox function is essential for growth stimulation [31]
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