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Discovery of ferroptosis-inducing R4VP compounds for targeting aggressive cancers
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Indeed, pharmacological or genetic inhibition of EV release (using GW4869 [126] , Rab27A knockdown [71] , inhibition of HSP70/HSP90-dependent EV release with omeprazole [127] or atractylenolide I treatment [128] ) has been shown to inhibit adipocyte transdifferentiation and lipolysis and to attenuate weight loss in mouse models of lung and colon cancer, supporting the therapeutic potential of EV-targeted therapies to disrupt the metabolic interplay between tumor cells and adipocytes that fuels tumor progression and cancer cachexia
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