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For instance, VB124 and MD-43, inhibitors of monocarboxylate transporter 4 (MCT4), enhance H3K18la levels through p300, driving macrophages toward a reparative phenotype characterized by increased anti-inflammatory and TCA cycle gene expression and reduced pro-inflammatory and glycolysis gene expression (75)

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Secondly, we have shown that a neurotoxic product of TRP metabolism, 3-OHKY, predicts severity of clinical symptoms during the early phase of illness and before exposure to antipsychotic drugs ( Lastly, optimum levels of purine metabolites have been associated with the dynamics of clinical symptoms and therapeutic improvements, which may lead to discovery of novel targets for drug development