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Gut 2022;71 (Suppl 3):A1–A96 [Google Scholar] 62.Komatsu Y, Sadakata I, Ogra Y, Suzuki KT

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For example, when the concentration of surfactant in the environment is lower than the CMC under specific pH conditions, it needs to be determined whether the solubilizing ability of surfactant will be affected by the formation of insoluble complexes between partially dissociated drug and surfactant due to the effect of electrostatic attraction between molecules with opposite charges, whether the solubilizing capacity of the surfactant will be reduced due to the repulsive interaction between the drug ions and the surfactant head between the drug and the surfactant of the same charge under specific pH conditions, whether there will be an interaction between ionic drug and non-ionic surfactant to drive the drug to the outside of the micellar core to reduce the surfactant CMC and thus increase the solubilising capacity of the surfactant at a given pH, and whether amphiphilic drugs and surfactants will be able to reduce the CMC due to the formation of mixed micelles at specific pH conditions, thereby increasing the solubilising capacity of surfactants