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(2017) reported that PE-22-28 inhibited the hTREK-1 channel with an IC₅₀ of approximately 0.12 nM, compared to full-length spadin’s IC₅₀ of 40–60 nM, indicating more than 300-fold greater potency in HEK cells expressing human TREK-1 channels
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Moderate deterioration in glucose tolerance during high-dose growth hormone therapy in glucocorticoid-treated patients with juvenile idiopathic arthritis
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