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5 Summary and outlook TME has been shown to play a key role in the occurrence, development, metastasis, and drug resistance of tumors

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These microbial metabolites contribute to damage associated with senescence-associated SASP by increasing the expression of inflammatory molecules such as TNF-α, IFN-γ, IL-1, IL-6, and MMPs, which in turn results in a persistent proinflammatory condition or inflammation (54)