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SODs in eukaryotes are divided into three types according to their binding metal cofactors and cellular localization, namely, copper–zinc superoxide dismutase (Cu/ZnSOD or SOD1) present in the cytoplasm or secreted into the extracellular fluid, manganese-containing superoxide dismutase (Mn-SOD or SOD 2 ) present in the mitochondrial matrix, and extracellular superoxide dismutase (EC-SOD or SOD 3 ) (Table 1) [6,14]
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