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BI 1291583, a selective cathepsin C (CatC) inhibitor, has shown dose-dependent CatC and NE suppression in phase I trials and demonstrated efficacy in the phase II AIRLEAF ® trial, significantly prolonging time to first exacerbation while maintaining a placebo-like safety profile, with further investigations ongoing in cystic fibrosis-related bronchiectasis and a planned phase III AIRTIVITY ® trial [77,78]
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