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Instead of targeting TAAs, UniCARs are engineered to recognize the human peptide sequence E5B9, also known as the UniCAR epitope, which is a fragment of the human nuclear autoantigen La/SS-B and absent in living cells (Jureczek et al., 2019)
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These data reveal an SFB colonization peak in humans at the end of the weaning period and within the first one to two, but up to 5 years of life
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