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These medications are broadly classified as either antiviral agents (nucleoside and nucleotide analogues) or immunomodulatory agents (interferon and peginterferon).[1,2,3] Several factors should be weighed when choosing an agent for initial treatment of an individual with chronic HBV infection: safety and efficacy of the treatment, risk of developing drug resistance, treatment duration, cost of therapy, and additional factors, such as liver disease severity or pregnancy