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15 Botulinum toxin can be used in patients with focal TD 16,18 and alternative therapeutic modalities such as short-term treatment with vitamin B 6 , amantadine or deep brain stimulation can be considered if patients do not respond to more established therapies
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A primary reason for increased glutaminolysis in IL-4-activated macrophages is the increased production of α-KG that contributes to the acquisition of an anti-inflammatory phenotype by altering the activity of the histone demethylase Jmjd3
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