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In addition to the valerolactone, 4-hydroxy-5-(3′,4′-dihydroxyphenyl)-valeric acid and 4-hydroxy-5-phenyl-valeric acid were detected as well in serum samples after intake of Pycnogenol ® ( 6.2 Systemic metabolism: conjugation and deconjugation Dietary polyphenols and microbial metabolites of procyanidins typically undergo a phase II metabolism in enterocytes and liver cells to form glucuronic acid, sulfate, and methyl conjugates (Figure 3) (73, 82, 83)
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