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Although xCT inhibition as a regulator of ferroptosis is a potential strategy for cancer therapy, the potential targets of ferroptosis in the treatment of ovarian cancer in vivo and their mechanisms remain poorly understood
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It downregulates p53 and upregulates the expression of SLC7A11 and GPX4, suggesting that it improves cartilage degradation in osteoarthritis by inhibiting ferroptosis through the regulation of the p53 signaling pathway, indicating its potential therapeutic effect in osteoarthritis [166]
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