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Thus, the accumulation of mutated mature blood cells arising from CH clones/pre-LSC can have an impact on atherosclerosis via monocytes/macrophages but also contribute to clonal expansion and in some rare cases give rise to frank leukemia
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Autophagy is a cellular mechanism that removes degraded/dysfunctional/misshaped components and plays a key role in preserving cell metabolic balance and in cell survival (358)
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