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Key Takeaways GHK Basic (Gly-His-Lys) is a naturally occurring tripeptide available for research purposes only, not FDA-approved for therapeutic use Clinical evidence remains primarily preclinical, with most human data limited to topical wound healing applications showing 20-30% improvement in healing rates [1] Measurable cellular effects typically appear within 7-14 days in laboratory studies, with peak collagen synthesis enhancement occurring at 3-4 weeks [2] Copper-binding affinity (Kd ~10^-16 M) drives the primary mechanism through metalloproteinase activation and gene expression modulation [3] Individual response varies significantly based on baseline copper status, with approximately 60-70% of study participants showing measurable biological response [4] Long-term safety data beyond 12 weeks is limited, and effects typically diminish within 2-4 weeks after discontinuation [5] What Is GHK Basic